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Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS.
Bravo-Hernandez, Mariana; Tadokoro, Takahiro; Navarro, Michael R; Platoshyn, Oleksandr; Kobayashi, Yoshiomi; Marsala, Silvia; Miyanohara, Atsushi; Juhas, Stefan; Juhasova, Jana; Skalnikova, Helena; Tomori, Zoltan; Vanicky, Ivo; Studenovska, Hana; Proks, Vladimir; Chen, PeiXi; Govea-Perez, Noe; Ditsworth, Dara; Ciacci, Joseph D; Gao, Shang; Zhu, Wenlian; Ahrens, Eric T; Driscoll, Shawn P; Glenn, Thomas D; McAlonis-Downes, Melissa; Da Cruz, Sandrine; Pfaff, Samuel L; Kaspar, Brian K; Cleveland, Don W; Marsala, Martin.
Afiliação
  • Bravo-Hernandez M; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Tadokoro T; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Navarro MR; Department of Anesthesiology, University of the Ryukyus, Okinawa, Japan.
  • Platoshyn O; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Kobayashi Y; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Marsala S; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Miyanohara A; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Juhas S; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Juhasova J; Vector Core Laboratory, University of California San Diego, La Jolla, CA, USA.
  • Skalnikova H; Institute of Animal Physiology and Genetics, AS CR v.v.i., Libechov, Czech Republic.
  • Tomori Z; Institute of Animal Physiology and Genetics, AS CR v.v.i., Libechov, Czech Republic.
  • Vanicky I; Institute of Animal Physiology and Genetics, AS CR v.v.i., Libechov, Czech Republic.
  • Studenovska H; Dept. of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia.
  • Proks V; Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovakia.
  • Chen P; Department of Biomaterials and Bioanalogous System, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Govea-Perez N; Department of Biomaterials and Bioanalogous System, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic.
  • Ditsworth D; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Ciacci JD; Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
  • Gao S; Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
  • Zhu W; Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
  • Ahrens ET; Department of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
  • Driscoll SP; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
  • Glenn TD; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
  • McAlonis-Downes M; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
  • Da Cruz S; Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Pfaff SL; Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Kaspar BK; Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
  • Cleveland DW; Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
  • Marsala M; Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA.
Nat Med ; 26(1): 118-130, 2020 01.
Article em En | MEDLINE | ID: mdl-31873312
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pia-Máter / Medula Espinal / Técnicas de Transferência de Genes / Dependovirus / Inativação Gênica / Esclerose Lateral Amiotrófica / Neurônios Motores / Degeneração Neural Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pia-Máter / Medula Espinal / Técnicas de Transferência de Genes / Dependovirus / Inativação Gênica / Esclerose Lateral Amiotrófica / Neurônios Motores / Degeneração Neural Idioma: En Ano de publicação: 2020 Tipo de documento: Article