Bone marrow infiltration by flow cytometry at diffuse large B-cell lymphoma NOS diagnosis implies worse prognosis without considering bone marrow histology.
Cytometry B Clin Cytom
; 98(6): 525-528, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-31873987
ABSTRACT
BACKGROUND:
The significance of discrepant findings between histology (BMB) and flow cytometry (FC) in bone marrow (BM) examination at diffuse large B-cell lymphoma (DLBCL) diagnosis is uncertain.METHODS:
We performed a 5-year retrospective single-center study of patients diagnosed by DLBCL not otherwise specified (n = 82), divided into three groups according to BM infiltration at diagnosis BMB-/FC- (75.6%), BMB+/FC+ (13.4%), and BMB-/FC+ (11%).RESULTS:
Median infiltration by FC analysis of the BMB-/FC+ group was 0.8% and if we considered BM infiltration as positive in all cases, 4/9 would be upstaged. Median follow was 33 months. Event-free survival (EFS) after 18 months was 82, 23, and 27% for BMB-/FC-, BMB-/FC+, and BMB+/FC+, respectively (p < .001). After 18 months of observation, OS was 87, 46, and 55% for BMB-/FC-, BMB-/FC+, and BMB+/FC+, respectively (p = .001). In multivariate analysis (BM infiltration vs. cell-of-origin according to Hans algorithm and standard IPI), BM infiltration was independently associated with EFS (HR 1.94, 95% CI 1.3-2.9) and overall survival (HR 1.69, 95% CI 1.1-2.7).CONCLUSION:
In summary, minimal BM infiltration, detected by FC but not by BMB, has same prognostic implications than overt BM infiltration and should be considered as extranodal involvement regardless the infiltration quantity.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Células da Medula Óssea
/
Linfoma Difuso de Grandes Células B
/
Infiltração Leucêmica
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Citometria de Fluxo
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article