CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma.
Med Oral Patol Oral Cir Bucal
; 25(1): e49-e55, 2020 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-31880289
ABSTRACT
BACKGROUND:
The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL ANDMETHODS:
Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified.RESULTS:
A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium.CONCLUSION:
The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrose Oral Submucosa
/
Neoplasias Bucais
/
Carcinoma de Células Escamosas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article