A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive ß-Cell Hyperplasia.

Kusminski, Christine M; Ghaben, Alexandra L; Morley, Thomas S; Samms, Ricardo J; Adams, Andrew C; An, Yu; Johnson, Joshua A; Joffin, Nolwenn; Onodera, Toshiharu; Crewe, Clair; Holland, William L; Gordillo, Ruth; Scherer, Philipp E

Kusminski, Christine M; Ghaben, Alexandra L; Morley, Thomas S; Samms, Ricardo J; Adams, Andrew C; An, Yu; Johnson, Joshua A; Joffin, Nolwenn; Onodera, Toshiharu; Crewe, Clair; Holland, William L; Gordillo, Ruth; Scherer, Philipp E.

Afiliação

Kusminski CM; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Ghaben AL; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Morley TS; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Samms RJ; Eli Lilly Research Laboratories, Division of Eli Lilly and Company, Indianapolis, IN.
Adams AC; Eli Lilly Research Laboratories, Division of Eli Lilly and Company, Indianapolis, IN.
An Y; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Johnson JA; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Joffin N; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Onodera T; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Crewe C; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Holland WL; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Gordillo R; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX.
Scherer PE; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX philipp.scherer@utsouthwestern.edu.

Diabetes ; 69(3): 313-330, 2020 03.

Article em En | MEDLINE | ID: mdl-31882562

Assuntos

Adipócitos/metabolismo; Ferritinas/genética; Intolerância à Glucose/metabolismo; Células Secretoras de Insulina/metabolismo; Mitocôndrias/metabolismo; Proteínas Mitocondriais/genética; Obesidade/metabolismo; Adiponectina/metabolismo; Tecido Adiposo Branco/metabolismo; Animais; Metabolismo Energético/genética; Ferritinas/metabolismo; Fatores de Crescimento de Fibroblastos/metabolismo; Técnica Clamp de Glucose; Fator 15 de Diferenciação de Crescimento/metabolismo; Hiperplasia; Resistência à Insulina/genética; Células Secretoras de Insulina/patologia; Camundongos; Camundongos Transgênicos; Proteínas Mitocondriais/metabolismo; Espécies Reativas de Oxigênio/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Intolerância à Glucose / Adipócitos / Proteínas Mitocondriais / Células Secretoras de Insulina / Ferritinas / Mitocôndrias / Obesidade Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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