Targeting Plasmodium Plasmepsin V: Hitting Two Birds with One Stone.

Brancucci, Nicolas M B; Heussler, Volker T; Grüring, Christof

Brancucci, Nicolas M B; Heussler, Volker T; Grüring, Christof.

Afiliação

Brancucci NMB; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address: nicolas.brancucci@swisstph.ch.
Heussler VT; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Grüring C; Institute of Cell Biology, University of Bern, Bern, Switzerland. Electronic address: christof.gruering@izb.unibe.ch.

Trends Parasitol ; 36(2): 85-87, 2020 02.

Article em En | MEDLINE | ID: mdl-31883707

ABSTRACT

ABSTRACT

A recent report by Jennison et al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these stages and that specific PMV inhibitors block parasite transmission to mosquitoes.

Assuntos

Ácido Aspártico Endopeptidases/antagonistas & inibidores; Ácido Aspártico Endopeptidases/metabolismo; Malária/parasitologia; Malária/transmissão; Plasmodium/enzimologia; Animais; Antimaláricos/farmacologia; Carbamatos/farmacologia; Humanos; Estágios do Ciclo de Vida/efeitos dos fármacos; Estágios do Ciclo de Vida/fisiologia; Malária/prevenção & controle; Oligopeptídeos/farmacologia; Plasmodium/efeitos dos fármacos; Transporte Proteico/efeitos dos fármacos

Palavras-chave

Anopheles mosquito; Plasmodium export element; aspartyl protease; gametocyte-exported proteins; malaria transmission; plasmepsin V

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium / Ácido Aspártico Endopeptidases / Malária Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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