The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects.
Food Chem Toxicol
; 136: 111069, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-31883992
ABSTRACT
Ionic liquids are a diverse range of charged chemicals with low volatility and often liquids at ambient temperatures. This characteristic has in part lead to them being considered environmentally-friendly replacements for existing volatile solvents. However, methylimidazolium ionic liquids are slow to break down in the environment and a recent study at Newcastle detected 1 octyl 3 methylimidazolium (M8OI) - an 8 carbon variant methylimidazolium ionic liquid - in soils in close proximity to a landfill site. The current M8OI toxicity database in cultured mammalian cells, in experimental animal studies and in model indicators of environmental impact are reviewed. Selected analytical data from the Newcastle study suggest the soils in close proximity to the landfill site, an urban soil lacking overt contamination, had variable levels of M8OI. The potential for M8OI - or a structurally related ionic liquid - to trigger primary biliary cholangitis (PBC), an autoimmune liver disease thought to be triggered by an unknown agent(s) in the environment, is reviewed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Líquidos Iônicos
/
Imidazóis
/
Fígado
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article