Suppression of transforming growth factor-beta signaling enhances spermatogonial proliferation and spermatogenesis recovery following chemotherapy.

Moraveji, Seyedeh-Faezeh; Esfandiari, Fereshteh; Taleahmad, Sara; Nikeghbalian, Saman; Sayahpour, Forough-Azam; Masoudi, Najmeh-Sadat; Shahverdi, Abdolhossein; Baharvand, Hossein

Moraveji, Seyedeh-Faezeh; Esfandiari, Fereshteh; Taleahmad, Sara; Nikeghbalian, Saman; Sayahpour, Forough-Azam; Masoudi, Najmeh-Sadat; Shahverdi, Abdolhossein; Baharvand, Hossein.

Afiliação

Moraveji SF; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Esfandiari F; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Taleahmad S; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Nikeghbalian S; Shiraz Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Sayahpour FA; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Masoudi NS; Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Shahverdi A; Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Baharvand H; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Hum Reprod ; 34(12): 2430-2442, 2019 12 01.

Article em En | MEDLINE | ID: mdl-31886487

Assuntos

Benzamidas/farmacologia; Dioxóis/farmacologia; Receptores de Fatores de Crescimento Transformadores beta/antagonistas & inibidores; Espermatogênese/efeitos dos fármacos; Espermatogônias/efeitos dos fármacos; Adolescente; Adulto; Animais; Feminino; Preservação da Fertilidade; Humanos; Masculino; Camundongos; Cultura Primária de Células; Espermatogônias/citologia

Palavras-chave

chemotherapy; male infertility; proliferation; small molecule; spermatogenesis; spermatogonial stem cells; transforming growth factor-beta signaling pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espermatogênese / Espermatogônias / Benzamidas / Receptores de Fatores de Crescimento Transformadores beta / Dioxóis Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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