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Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells.
Leem, Galam; Kim, Beom Kyung; Shin, Eui Cheol; Park, Jun Yong.
Afiliação
  • Leem G; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
  • Kim BK; Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital, Seoul, Korea.
  • Shin EC; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. ecshin@kaist.ac.kr.
  • Park JY; Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital, Seoul, Korea. drpjy@yuhs.ac.
Yonsei Med J ; 61(1): 100-102, 2020 Jan.
Article em En | MEDLINE | ID: mdl-31887806
To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Falência Hepática / Linfócitos T Reguladores / Hepatite Autoimune / Hepatite A / Inflamação Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Falência Hepática / Linfócitos T Reguladores / Hepatite Autoimune / Hepatite A / Inflamação Idioma: En Ano de publicação: 2020 Tipo de documento: Article