QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a Potent CK2 Inhibitor.

Haidar, Samer; Marminon, Christelle; Aichele, Dagmar; Nacereddine, Abdelhamid; Zeinyeh, Wael; Bouzina, Abdeslem; Berredjem, Malika; Ettouati, Laurent; Bouaziz, Zouhair; Le Borgne, Marc; Jose, Joachim

Haidar, Samer; Marminon, Christelle; Aichele, Dagmar; Nacereddine, Abdelhamid; Zeinyeh, Wael; Bouzina, Abdeslem; Berredjem, Malika; Ettouati, Laurent; Bouaziz, Zouhair; Le Borgne, Marc; Jose, Joachim.

Afiliação

Haidar S; Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Westfälische Wilhelms-Universität Münster, Corrensstr. 48, 48149 Münster, Germany.
Marminon C; Faculty of Pharmacy, 17 April street, Damascus University, Damascus P.O. Box 9411, Syria.
Aichele D; Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7, Université de Lyon, Université Claude Bernard Lyon 1, 8 Avenue Rockefeller, F-69373 Lyon CEDEX 8, France.
Nacereddine A; Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Westfälische Wilhelms-Universität Münster, Corrensstr. 48, 48149 Münster, Germany.
Zeinyeh W; Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7, Université de Lyon, Université Claude Bernard Lyon 1, 8 Avenue Rockefeller, F-69373 Lyon CEDEX 8, France.
Bouzina A; Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7, Université de Lyon, Université Claude Bernard Lyon 1, 8 Avenue Rockefeller, F-69373 Lyon CEDEX 8, France.
Berredjem M; Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7, Université de Lyon, Université Claude Bernard Lyon 1, 8 Avenue Rockefeller, F-69373 Lyon CEDEX 8, France.
Ettouati L; Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar-Annaba University, Box 12, Annaba 23000, Algeria.
Bouaziz Z; Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar-Annaba University, Box 12, Annaba 23000, Algeria.
Le Borgne M; Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7, Université de Lyon, Université Claude Bernard Lyon 1, 8 Avenue Rockefeller, F-69373 Lyon CEDEX 8, France.
Jose J; Faculté de Pharmacie-ISPB, EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7, Université de Lyon, Université Claude Bernard Lyon 1, 8 Avenue Rockefeller, F-69373 Lyon CEDEX 8, France.

Molecules ; 25(1)2019 Dec 26.

Article em En | MEDLINE | ID: mdl-31888043

Assuntos

Caseína Quinase II/antagonistas & inibidores; Furanos/síntese química; Inibidores de Proteínas Quinases/síntese química; Caseína Quinase II/química; Sobrevivência Celular/efeitos dos fármacos; Furanos/química; Furanos/farmacologia; Humanos; Indóis/síntese química; Indóis/química; Concentração Inibidora 50; Células MCF-7; Modelos Moleculares; Estrutura Molecular; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/farmacologia; Relação Quantitativa Estrutura-Atividade

Palavras-chave

CK2; QSAR; cancer; indeno[1,2-b]indole; naphtho[2,3-b]furan-4,9-dione

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caseína Quinase II / Inibidores de Proteínas Quinases / Furanos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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