The effect of Liv-52 on liver ischemia reperfusion damage in rats.
BMC Pharmacol Toxicol
; 21(1): 2, 2020 01 03.
Article
em En
| MEDLINE
| ID: mdl-31900219
ABSTRACT
BACKGROUND:
Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats.METHODS:
Albino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals.RESULTS:
Increased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically.CONCLUSIONS:
Liv-52 may be beneficial for preventing liver I/R damage in pre-surgery application.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Traumatismo por Reperfusão
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Fígado
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Antioxidantes
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article