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Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes.
Williams, Jason H; Udata, Chandrasekhar; Ganguly, Bishu J; Bucktrout, Samantha L; Joh, Tenshang; Shannon, Megan; Wong, Gilbert Y; Levisetti, Matteo; Garzone, Pamela D; Meng, Xu.
Afiliação
  • Williams JH; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA. jason.williams@pfizer.com.
  • Udata C; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA.
  • Ganguly BJ; Pfizer Inc, South San Francisco, California, USA.
  • Bucktrout SL; Lyell Immunopharma, South San Francisco, California, USA.
  • Joh T; Pfizer Inc, South San Francisco, California, USA.
  • Shannon M; Parker Institute for Cancer Immunotherapy, San Francisco, California, USA.
  • Wong GY; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA.
  • Levisetti M; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA.
  • Garzone PD; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA.
  • Meng X; Worldwide Research & Development, Pfizer Inc, 10777 Science Center Dr, CB1/1130, San Diego, California, 92121, USA.
AAPS J ; 22(2): 23, 2020 01 03.
Article em En | MEDLINE | ID: mdl-31900603
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina / Receptores de Interleucina-17 / Anticorpos Monoclonais Humanizados / Hipoglicemiantes / Modelos Biológicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina / Receptores de Interleucina-17 / Anticorpos Monoclonais Humanizados / Hipoglicemiantes / Modelos Biológicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article