Effects of cyclophosphamide and a metabolite, acrolein, on Naegleria fowleri in vitro and in vivo.
Antimicrob Agents Chemother
; 32(7): 962-5, 1988 Jul.
Article
em En
| MEDLINE
| ID: mdl-3190198
ABSTRACT
Mice challenged intranasally with Naegleria fowleri died of primary amoebic meningoencephalitis. Mice given 30 mg of cyclophosphamide per kg of body weight daily for 10 days starting 2 days before challenge were protected. Neither cyclophosphamide nor serum from cyclophosphamide-treated mice inhibited N. fowleri in vitro. A metabolic product of cyclophosphamide, acrolein, inhibited growth and enflagellation of N. fowleri. Acrolein at 40 microM was amoebicidal. Acrolein injured starved cells and amoebae at 5 degrees C and growing N. fowleri.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acroleína
/
Naegleria
/
Ciclofosfamida
/
Aldeídos
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article