Enhanced Loading of Functional miRNA Cargo via pH Gradient Modification of Extracellular Vesicles.

Jeyaram, Anjana; Lamichhane, Tek N; Wang, Sheng; Zou, Lin; Dahal, Eshan; Kronstadt, Stephanie M; Levy, Daniel; Parajuli, Babita; Knudsen, Daphne R; Chao, Wei; Jay, Steven M

Jeyaram, Anjana; Lamichhane, Tek N; Wang, Sheng; Zou, Lin; Dahal, Eshan; Kronstadt, Stephanie M; Levy, Daniel; Parajuli, Babita; Knudsen, Daphne R; Chao, Wei; Jay, Steven M.

Afiliação

Jeyaram A; Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Lamichhane TN; Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Wang S; Translational Research Program, Department of Anesthesiology and Center for Shock Trauma Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Zou L; Translational Research Program, Department of Anesthesiology and Center for Shock Trauma Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Dahal E; Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Kronstadt SM; Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Levy D; Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Parajuli B; Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Knudsen DR; Program in Molecular and Cell Biology, University of Maryland, College Park, MD, USA.
Chao W; Translational Research Program, Department of Anesthesiology and Center for Shock Trauma Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Jay SM; Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA; Program in Molecular and Cell Biology, University of Maryland, College Park, MD, USA. Electronic address: smjay@umd.edu.

Mol Ther ; 28(3): 975-985, 2020 03 04.

Article em En | MEDLINE | ID: mdl-31911034

Assuntos

Vesículas Extracelulares/metabolismo; Concentração de Íons de Hidrogênio; MicroRNAs/metabolismo; Transporte Biológico; Vesículas Extracelulares/ultraestrutura; Células HEK293; Humanos; MicroRNAs/genética; Ácidos Nucleicos/metabolismo

Palavras-chave

exosomes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Vesículas Extracelulares / Concentração de Íons de Hidrogênio Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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