Upexpression of BHLHE40 in gastric epithelial cells increases CXCL12 production through interaction with p-STAT3 in Helicobacter pylori-associated gastritis.
FASEB J
; 34(1): 1169-1181, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31914631
ABSTRACT
BHLHE40, a member of the basic helix-loop-helix transcription factor family, has been reported to play an important role in inflammatory diseases. However, the regulation and function of BHLHE40 in Helicobacter pylori (H pylori)-associated gastritis is unknown. We observed that gastric BHLHE40 was significantly elevated in patients and mice with H pylori infection. Then, we demonstrate that H pylori-infected GECs express BHLHE40 via cagA-ERK pathway. BHLHE40 translocates to cell nucleus, and then binds to cagA protein-activated p-STAT3 (Tyr705). The complex increases chemotactic factor CXCL12 expression (production). Release of CXCL12 from GECs fosters CD4+ T cell infiltration in the gastric mucosa. Our results identify the cagA-BHLHE40-CXCL12 axis that contributes to inflammatory response in gastric mucosa during H pylori infection.
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MEDLINE
Assunto principal:
Infecções por Helicobacter
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Proteínas de Homeodomínio
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Células Epiteliais
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Fator de Transcrição STAT3
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Fatores de Transcrição Hélice-Alça-Hélice Básicos
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Quimiocina CXCL12
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Gastrite
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article