Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-&#954;B p65 and MAPK signaling pathways in septic AKI mice.

Ren, Qian; Guo, Fan; Tao, Sibei; Huang, Rongshuang; Ma, Liang; Fu, Ping

Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice.

Ren, Qian; Guo, Fan; Tao, Sibei; Huang, Rongshuang; Ma, Liang; Fu, Ping.

Afiliação

Ren Q; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Guo F; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Tao S; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Huang R; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Ma L; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address: liang_m@scu.edu.cn.
Fu P; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.

Biomed Pharmacother ; 122: 109772, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31918290

Assuntos

Injúria Renal Aguda/tratamento farmacológico; Apoptose/efeitos dos fármacos; Flavonoides/farmacologia; Inflamação/tratamento farmacológico; Sepse/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos; Injúria Renal Aguda/metabolismo; Animais; Flavonóis; Genes src/efeitos dos fármacos; Inflamação/metabolismo; Rim/efeitos dos fármacos; Lipopolissacarídeos/farmacologia; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Sepse/metabolismo; Fator de Transcrição RelA/metabolismo

Palavras-chave

Acute kidney injury; Apoptosis; Fisetin; Inflammation; Lipopolysaccharide; Sepsis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Transdução de Sinais / Apoptose / Sepse / Injúria Renal Aguda / Inflamação Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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