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Design, synthesis and biological evaluation of novel TRß selective agonists sustained by ADME-toxicity analysis.
Runfola, Massimiliano; Sestito, Simona; Bellusci, Lorenza; La Pietra, Valeria; D'Amore, Vincenzo Maria; Kowalik, Marta Anna; Chiellini, Grazia; Gul, Sheraz; Perra, Andrea; Columbano, Amedeo; Marinelli, Luciana; Novellino, Ettore; Rapposelli, Simona.
Afiliação
  • Runfola M; Department of Pharmacy, University of Pisa, Pisa, 56126, Italy.
  • Sestito S; Department of Pharmacy, University of Pisa, Pisa, 56126, Italy.
  • Bellusci L; Department of Pathology, University of Pisa, Pisa, 56126, Italy.
  • La Pietra V; Department of Pharmacy, University of Naples Federico II, Italy.
  • D'Amore VM; Department of Pharmacy, University of Naples Federico II, Italy.
  • Kowalik MA; Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, Italy.
  • Chiellini G; Department of Pathology, University of Pisa, Pisa, 56126, Italy. Electronic address: grazia.chiellini@unipi.it.
  • Gul S; Fraunhofer Institute for Molecular Biology & Applied Ecology - ScreeningPort, Hamburg, Germany.
  • Perra A; Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, Italy.
  • Columbano A; Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, Italy.
  • Marinelli L; Department of Pharmacy, University of Naples Federico II, Italy.
  • Novellino E; Department of Pharmacy, University of Naples Federico II, Italy.
  • Rapposelli S; Department of Pharmacy, University of Pisa, Pisa, 56126, Italy; Interdepartmental Research Centre for Biology and Pathology of Aging, University of Pisa, Pisa, Italy. Electronic address: simona.rapposelli@unipi.it.
Eur J Med Chem ; 188: 112006, 2020 Feb 15.
Article em En | MEDLINE | ID: mdl-31931337
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Uracila / Desenho de Fármacos / Receptores beta dos Hormônios Tireóideos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Uracila / Desenho de Fármacos / Receptores beta dos Hormônios Tireóideos Idioma: En Ano de publicação: 2020 Tipo de documento: Article