Mesoporous silica with precisely controlled pores reduces food efficiency and suppresses weight gain in mice.
Nanomedicine (Lond)
; 15(2): 131-144, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31933414
ABSTRACT
Aim:
Obesity is a risk factor for cardiovascular disease and diabetes. We aimed to elucidate the effects of distinct mesoporous silica particles (MSPs) supplemented in food on metabolic parameters in obesity. Materials &methods:
MSPs with precisely controlled pore size were synthesized, characterized and compared with a control in a C57Bl/6 mouse diet-induced obesity model, studying weight, adiposity, metabolic regulation and food efficiency.Results:
The most effective MSPs reduced adipose tissue formation to 6.5 ± 0.5 g compared with 9.4 ± 1.2 g, leptin levels nearly halved from 32.8 ± 7.4 to 16.9 ± 1.9 ng/ml and a 33% reduction of food efficiency. Control MSP showed no effects.Conclusion:
Results demonstrate potential of distinct MSPs to improve metabolic risk factors. Further studies investigating mechanism of action and confirming human safety are needed.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aumento de Peso
/
Dióxido de Silício
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Nanopartículas
/
Obesidade
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article