CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention.

Pugacheva, Elena M; Kubo, Naoki; Loukinov, Dmitri; Tajmul, Md; Kang, Sungyun; Kovalchuk, Alexander L; Strunnikov, Alexander V; Zentner, Gabriel E; Ren, Bing; Lobanenkov, Victor V

Pugacheva, Elena M; Kubo, Naoki; Loukinov, Dmitri; Tajmul, Md; Kang, Sungyun; Kovalchuk, Alexander L; Strunnikov, Alexander V; Zentner, Gabriel E; Ren, Bing; Lobanenkov, Victor V.

Afiliação

Pugacheva EM; Molecular Pathology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; epugacheva@niaid.nih.gov vlobanenkov@niaid.nih.gov.
Kubo N; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093.
Loukinov D; Molecular Pathology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Tajmul M; Molecular Pathology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Kang S; Department of Biology, Indiana University, Bloomington, IN 47405.
Kovalchuk AL; Molecular Pathology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Strunnikov AV; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Science Park, 510530 Guangzhou, China.
Zentner GE; Department of Biology, Indiana University, Bloomington, IN 47405.
Ren B; Indiana University Melvin and Bren Simon Cancer Center, Indiana University-Purdue University, Indianapolis, IN 46202.
Lobanenkov VV; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093.

Proc Natl Acad Sci U S A ; 117(4): 2020-2031, 2020 01 28.

Article em En | MEDLINE | ID: mdl-31937660

Assuntos

Neoplasias da Mama/metabolismo; Fator de Ligação a CCCTC/metabolismo; Proteínas de Ciclo Celular/metabolismo; Cromatina/metabolismo; Proteínas Cromossômicas não Histona/metabolismo; DNA de Neoplasias/metabolismo; Sítios de Ligação; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Fator de Ligação a CCCTC/genética; Proteínas de Ciclo Celular/genética; Cromatina/genética; Proteínas Cromossômicas não Histona/genética; DNA de Neoplasias/genética; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Feminino; Genoma Humano; Humanos; Ligação Proteica; Domínios Proteicos; Células Tumorais Cultivadas; Coesinas

Palavras-chave

3D genome organization; BORIS; CTCF; cohesin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / DNA de Neoplasias / Cromatina / Proteínas Cromossômicas não Histona / Proteínas de Ciclo Celular / Fator de Ligação a CCCTC Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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