A palladium-catalyst stabilized in the chiral environment of a monoclonal antibody in water.
Chem Commun (Camb)
; 56(10): 1605-1607, 2020 Feb 04.
Article
em En
| MEDLINE
| ID: mdl-31939465
ABSTRACT
We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst consisting of the Pd-complex and mAb selectively gives the (R)-enantiomer product with an enantiomeric excess (ee) of 98 ± 2%. This is in sharp contrast to the reaction catalyzed by a conventional Pd-catalyst (ee < 2%).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paládio
/
Complexos de Coordenação
/
Anticorpos Monoclonais
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article