[Risk factors for cow's milk protein allergy in infants: a multicenter survey].
Zhongguo Dang Dai Er Ke Za Zhi
; 22(1): 42-46, 2020 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-31948523
ABSTRACT
OBJECTIVE:
To investigate the risk factors for cow's milk protein allergy (CMPA) among infants through a multicenter clinical study.METHODS:
A total of 1 829 infants, aged 1-12 months, who attended the outpatient service of the pediatric department in six hospitals in Shenzhen, China from June 2016 to May 2017 were enrolled as subjects. A questionnaire survey was performed to screen out suspected cases of CMPA. Food avoidance and oral food challenge tests were used to make a confirmed diagnosis of CMPA CMPA. A multivariate logistic regression analysis was used to investigate the risk factors for CMPA.RESULTS:
Among the 1 829 infants, 82 (4.48%) were diagnosed with CMPA. The multivariate logistic regression analysis showed that maternal food allergy (OR=4.91, 95%CI 2.24-10.76, P<0.05), antibiotic exposure during pregnancy (OR=3.18, 95%CI 1.32-7.65, P<0.05), and the introduction of complementary food at an age of <4 months (OR=3.55, 95%CI 1.52-8.27, P<0.05) were risk factors for CMPA, while exclusive breastfeeding (OR=0.21, 95%CI 0.08-0.58, P<0.05) and the introduction of complementary food at an age of >6 months (OR=0.38, 95%CI 0.17-0.86, P<0.05) were protective factors.CONCLUSIONS:
The introduction of complementary food at an age of <4 months, maternal food allergy, and antibiotic exposure during pregnancy are risk factors for CMPA in infants.
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MEDLINE
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Hipersensibilidade a Leite
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article