Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis in Human TNF-<i>&#945;</i> Transgenic Mice.

Seki, Iwao; Takai-Imamura, Miwa; Kohara-Tanaka, Tomomi; Shirae, Satoshi; Sasano, Minoru; Matsuno, Hiroaki; Aono, Hiroyuki

Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis in Human TNF-α Transgenic Mice.

Seki, Iwao; Takai-Imamura, Miwa; Kohara-Tanaka, Tomomi; Shirae, Satoshi; Sasano, Minoru; Matsuno, Hiroaki; Aono, Hiroyuki.

Afiliação

Seki I; Research and Development Department, AYUMI Pharmaceutical Corporation, 8F Shijyo-Karasuma FT Square, 20 Naginatahoko-cho, Shimogyo-ku, Kyoto 600-8008, Japan.
Takai-Imamura M; Research and Development Department, AYUMI Pharmaceutical Corporation, 8F Shijyo-Karasuma FT Square, 20 Naginatahoko-cho, Shimogyo-ku, Kyoto 600-8008, Japan.
Kohara-Tanaka T; Research and Development Department, AYUMI Pharmaceutical Corporation, 8F Shijyo-Karasuma FT Square, 20 Naginatahoko-cho, Shimogyo-ku, Kyoto 600-8008, Japan.
Shirae S; Research and Development Department, AYUMI Pharmaceutical Corporation, 8F Shijyo-Karasuma FT Square, 20 Naginatahoko-cho, Shimogyo-ku, Kyoto 600-8008, Japan.
Sasano M; Research and Development Department, AYUMI Pharmaceutical Corporation, 8F Shijyo-Karasuma FT Square, 20 Naginatahoko-cho, Shimogyo-ku, Kyoto 600-8008, Japan.
Matsuno H; Matsuno Clinic for Rheumatic Disease, 7187-2, Kureha-cho, Toyama-shi, Toyama 930-0138, Japan.
Aono H; Research and Development Department, AYUMI Pharmaceutical Corporation, 8F Shijyo-Karasuma FT Square, 20 Naginatahoko-cho, Shimogyo-ku, Kyoto 600-8008, Japan.

Mediators Inflamm ; 2019: 4176974, 2019.

Article em En | MEDLINE | ID: mdl-31949424

Assuntos

Antirreumáticos/uso terapêutico; Artrite Reumatoide/tratamento farmacológico; Artrite Reumatoide/metabolismo; Etanercepte/uso terapêutico; Metaloproteinase 3 da Matriz/metabolismo; Tacrolimo/uso terapêutico; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo; Animais; Antirreumáticos/administração & dosagem; Artrite Experimental/diagnóstico por imagem; Artrite Experimental/tratamento farmacológico; Artrite Experimental/metabolismo; Artrite Reumatoide/diagnóstico por imagem; Reabsorção Óssea/genética; Progressão da Doença; Etanercepte/administração & dosagem; Humanos; Masculino; Metaloproteinase 3 da Matriz/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Tacrolimo/administração & dosagem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Fator de Necrose Tumoral alfa / Tacrolimo / Antirreumáticos / Metaloproteinase 3 da Matriz / Etanercepte Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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