LCK inhibitor attenuates atherosclerosis in ApoE<sup>-/-</sup> mice via regulating T cell differentiation and reverse cholesterol transport.

Liu, Jichen; Guo, Zhongzhou; Zhang, Yanan; Wu, Tongwei; Ma, Yusheng; Lai, Wenyan; Guo, Zhigang

LCK inhibitor attenuates atherosclerosis in ApoE^-/- mice via regulating T cell differentiation and reverse cholesterol transport.

Liu, Jichen; Guo, Zhongzhou; Zhang, Yanan; Wu, Tongwei; Ma, Yusheng; Lai, Wenyan; Guo, Zhigang.

Afiliação

Liu J; Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China.
Guo Z; Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China.
Zhang Y; Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China.
Wu T; Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China.
Ma Y; Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China.
Lai W; Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China.
Guo Z; Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China. Electronic address: guo_zhigang163@163.com.

J Mol Cell Cardiol ; 139: 87-97, 2020 02.

Article em En | MEDLINE | ID: mdl-31972265

Assuntos

Apolipoproteínas E/deficiência; Diferenciação Celular; Colesterol/metabolismo; Proteína Tirosina Quinase p56(lck) Linfócito-Específica/antagonistas & inibidores; Linfócitos T/citologia; Linfócitos T/metabolismo; Animais; Aterosclerose/sangue; Aterosclerose/metabolismo; Aterosclerose/patologia; Transporte Biológico/efeitos dos fármacos; Diferenciação Celular/efeitos dos fármacos; Dieta Hiperlipídica; Lipídeos/sangue; Proteína Tirosina Quinase p56(lck) Linfócito-Específica/metabolismo; Masculino; Camundongos; Modelos Biológicos; Necrose; Fosfatidilinositol 3-Quinases/metabolismo; Placa Aterosclerótica/sangue; Placa Aterosclerótica/patologia; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Células RAW 264.7; Transdução de Sinais/efeitos dos fármacos; Linfócitos T/efeitos dos fármacos; Serina-Treonina Quinases TOR/metabolismo; Regulação para Cima/efeitos dos fármacos

Palavras-chave

Atherosclerosis; Inflammation; LCK; Reverse cholesterol capacity; T cell differentiation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Linfócitos T / Diferenciação Celular / Colesterol / Proteína Tirosina Quinase p56(lck) Linfócito-Específica Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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