Meropenem to Children With Febrile Neutropenia Induces Monoresistant Pseudomonas aeruginosa.
J Pediatr Hematol Oncol
; 42(8): e783-e787, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-31972720
ABSTRACT
Antimicrobial resistance in Pseudomonas aeruginosa is a threat to children with cancer. We explored the association between P. aeruginosa resistance and previous antibiotic exposure. All children with cancer and P. aeruginosa bacteremia in 2007 to 2016 in Denmark, a country with an overall resistance rate of â¼3%, were included. Twenty percent (10/49) of isolates from children previously exposed to meropenem were meropenem nonsusceptible. The only significant risk factor of meropenem nonsusceptibility was previous meropenem therapy (P=0.03). On the basis of these results, we suggest that meropenem should be reserved as a last resort for children with febrile neutropenia in countries with low antimicrobial resistance.
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Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
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Infecções por Pseudomonas
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Neutropenia Febril
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Meropeném
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Antibacterianos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article