Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic Role.
Curr Mol Med
; 20(7): 516-526, 2020.
Article
em En
| MEDLINE
| ID: mdl-31995005
ABSTRACT
Circular RNAs, a group of endogenous non-coding RNAs, are characterized by covalently closed cyclic structures with no poly-adenylated tails. It has been recently recommended that cirRNAs have an essential role in regulating genes expression by functioning as a translational regulator, RNA binding protein sponge and microRNA sponge. Due to their close relation to the progression of various diseases such as diabetes, circRNAs have become a research hotspot. A number of circRNAs (i.e., circRNA_0054633, circHIPK3, circANKRD36, and circRNA11783-2) have been shown to be associated with initiation and progression of diabetes. Based on reports, in a tissue, some circRNAs are expressed in a developmental stage-specific manner. In this study, we reviewed research on circular RNAs involved in the pathogenesis and diagnosis of diabetes and their prognostic roles.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
Epigênese Genética
/
Diabetes Mellitus
/
RNA Circular
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article