Biodegradable polymer nanocomposites for ligament/tendon tissue engineering.
J Nanobiotechnology
; 18(1): 23, 2020 Jan 30.
Article
em En
| MEDLINE
| ID: mdl-32000800
ABSTRACT
Ligaments and tendons are fibrous tissues with poor vascularity and limited regeneration capacity. Currently, a ligament/tendon injury often require a surgical procedure using auto- or allografts that present some limitations. These inadequacies combined with the significant economic and health impact have prompted the development of tissue engineering approaches. Several natural and synthetic biodegradable polymers as well as composites, blends and hybrids based on such materials have been used to produce tendon and ligament scaffolds. Given the complex structure of native tissues, the production of fiber-based scaffolds has been the preferred option for tendon/ligament tissue engineering. Electrospinning and several textile methods such as twisting, braiding and knitting have been used to produce these scaffolds. This review focuses on the developments achieved in the preparation of tendon/ligament scaffolds based on different biodegradable polymers. Several examples are overviewed and their processing methodologies, as well as their biological and mechanical performances, are discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Tendões
/
Materiais Biocompatíveis
/
Nanocompostos
/
Alicerces Teciduais
/
Ligamentos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article