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Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.
Shah, Rishi R; Redmond, Joanna M; Mihut, Andrei; Menon, Malini; Evans, John P; Murphy, John A; Bartholomew, Michelle A; Coe, Diane M.
Afiliação
  • Shah RR; Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom; Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom. Electronic address: Rishi.x.shah@gsk.com.
  • Redmond JM; Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.
  • Mihut A; Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.
  • Menon M; Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.
  • Evans JP; Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.
  • Murphy JA; Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
  • Bartholomew MA; Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.
  • Coe DM; Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.
Bioorg Med Chem ; 28(5): 115326, 2020 03 01.
Article em En | MEDLINE | ID: mdl-32001089
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Quinoxalinas / Ubiquitina / Fatores de Transcrição STAT / Janus Quinases / Proteólise Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Quinoxalinas / Ubiquitina / Fatores de Transcrição STAT / Janus Quinases / Proteólise Idioma: En Ano de publicação: 2020 Tipo de documento: Article