Substrate specificities of Fusarium biosynthetic enzymes explain the genetic basis of a mixed chemotype producing both deoxynivalenol and nivalenol-type trichothecenes.

Maeda, Kazuyuki; Tanaka, Yuya; Matsuyama, Momoko; Sato, Masayuki; Sadamatsu, Kazuki; Suzuki, Tamotsu; Matsui, Kosuke; Nakajima, Yuichi; Tokai, Takeshi; Kanamaru, Kyoko; Ohsato, Shuichi; Kobayashi, Tetsuo; Fujimura, Makoto; Nishiuchi, Takumi; Takahashi-Ando, Naoko; Kimura, Makoto

Maeda, Kazuyuki; Tanaka, Yuya; Matsuyama, Momoko; Sato, Masayuki; Sadamatsu, Kazuki; Suzuki, Tamotsu; Matsui, Kosuke; Nakajima, Yuichi; Tokai, Takeshi; Kanamaru, Kyoko; Ohsato, Shuichi; Kobayashi, Tetsuo; Fujimura, Makoto; Nishiuchi, Takumi; Takahashi-Ando, Naoko; Kimura, Makoto.

Afiliação

Maeda K; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan; Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan.
Tanaka Y; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.
Matsuyama M; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.
Sato M; Graduate School of Life Sciences, Toyo University, Itakura, Gunma, Japan.
Sadamatsu K; Graduate School of Science and Engineering, Toyo University, Kawagoe, Saitama, Japan.
Suzuki T; Graduate School of Science and Engineering, Toyo University, Kawagoe, Saitama, Japan.
Matsui K; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan; Graduate School of Science and Engineering, Toyo University, Kawagoe, Saitama, Japan.
Nakajima Y; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.
Tokai T; Graduate School of Life Sciences, Toyo University, Itakura, Gunma, Japan.
Kanamaru K; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan; Department of Biological Chemistry, Chubu University, Kasugai, Aichi, Japan.
Ohsato S; Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan.
Kobayashi T; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.
Fujimura M; Graduate School of Life Sciences, Toyo University, Itakura, Gunma, Japan.
Nishiuchi T; Division of Functional Genomics, Advanced Science Research Centre, Kanazawa University, Kanazawa, Ishikawa, Japan.
Takahashi-Ando N; Graduate School of Science and Engineering, Toyo University, Kawagoe, Saitama, Japan.
Kimura M; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan. Electronic address: mkimura@agr.nagoya-u.ac.jp.

Int J Food Microbiol ; 320: 108532, 2020 May 02.

Article em En | MEDLINE | ID: mdl-32004825

Assuntos

Fusarium/genética; Fusarium/metabolismo; Tricotecenos/metabolismo; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Evolução Biológica; Vias Biossintéticas/genética; Fusarium/enzimologia; Mutação; Micotoxinas/química; Micotoxinas/metabolismo; Especificidade por Substrato; Tricotecenos/química

Palavras-chave

15-Acetyldeoxynivalenol (PubChem CID: 10382483); 15-Acetylnivalenol (PubChem CID: 132559605); 3-Acetyldeoxynivalenol (PubChem CID: 5458510); 3-Acetylnivalenol; 4-Acetylnivalenol (PubChem CID: 102515408); Artificial metabolic route; Cytochrome P450 monooxygenase; Deoxynivalenol (PubChem CID: 40024); Fusarium graminearum; Nivalenol (PubChem CID: 5284433); Trichothecene deacetylase; Type B trichothecene mycotoxin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tricotecenos / Fusarium Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tricotecenos / Fusarium Idioma: En Ano de publicação: 2020 Tipo de documento: Article