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The Association of MMP7 Promoter Polymorphisms With Gastric Cancer.
Fu, Chun-Kai; Chien, Yi-Chun; Chuang, Hui-Yen; Wang, Yun-Chi; Hwang, Jeng-Jong; Yang, Mei-Due; Yu, Chien-Chih; Chen, Jaw-Chyun; Chang, Wen-Shin; Bau, DA-Tian; Tsai, Chia-Wen.
Afiliação
  • Fu CK; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
  • Chien YC; Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
  • Chuang HY; Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Wang YC; Department of Medical Imaging and Radiological Sciences, I-Shou University, Jiaosu Village, Kaohsiung, Taiwan, R.O.C.
  • Hwang JJ; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, R.O.C.
  • Yang MD; Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Yu CC; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, R.O.C.
  • Chen JC; Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Chang WS; Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Bau DT; Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Tsai CW; Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
Anticancer Res ; 40(2): 695-702, 2020 Feb.
Article em En | MEDLINE | ID: mdl-32014910
BACKGROUND/AIM: Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time. MATERIALS AND METHODS: A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum. RESULTS: The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population. CONCLUSION: The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Metaloproteinase 7 da Matriz Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Metaloproteinase 7 da Matriz Idioma: En Ano de publicação: 2020 Tipo de documento: Article