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Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe.
Zhang, Meng-Meng; Ma, Yin-Hua; Li, Peng; Jia, Yan; Han, Ke-Li.
Afiliação
  • Zhang MM; State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China. klhan@dicp.ac.cn and University of the Chinese Academy of Sciences, Beijing 100049, P. R. China.
  • Ma YH; State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China. klhan@dicp.ac.cn and University of the Chinese Academy of Sciences, Beijing 100049, P. R. China.
  • Li P; Shandong University, P. R. China.
  • Jia Y; State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China. klhan@dicp.ac.cn.
  • Han KL; State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China. klhan@dicp.ac.cn.
Chem Commun (Camb) ; 56(17): 2610-2613, 2020 Feb 27.
Article em En | MEDLINE | ID: mdl-32016272
ABSTRACT
We have synthesized a turn-on fluorescent probe, termed NB4OH, to detect cellular hypochlorite. NB4OH is mainly localized in the endoplasmic reticulum and detects ClO- in foam cells. The fluorescence change of the probe was explained by theoretical calculation as a PET process. The probe holds great promise for application in biomedical research, including atherosclerosis research.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sondas Moleculares / Ácido Hipocloroso / Retículo Endoplasmático / Aterosclerose / Células Espumosas Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sondas Moleculares / Ácido Hipocloroso / Retículo Endoplasmático / Aterosclerose / Células Espumosas Idioma: En Ano de publicação: 2020 Tipo de documento: Article