Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe.
Chem Commun (Camb)
; 56(17): 2610-2613, 2020 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-32016272
ABSTRACT
We have synthesized a turn-on fluorescent probe, termed NB4OH, to detect cellular hypochlorite. NB4OH is mainly localized in the endoplasmic reticulum and detects ClO- in foam cells. The fluorescence change of the probe was explained by theoretical calculation as a PET process. The probe holds great promise for application in biomedical research, including atherosclerosis research.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sondas Moleculares
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Ácido Hipocloroso
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Retículo Endoplasmático
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Aterosclerose
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Células Espumosas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article