Cobalt-Catalyzed Hydroamination of Alkenes with 5-Substituted Tetrazoles: Facile Access to 2,5-Disubstituted Tetrazoles and Asymmetric Intermolecular Hydroaminations.
Chem Pharm Bull (Tokyo)
; 68(4): 332-335, 2020 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-32023589
ABSTRACT
Herein, we describe a novel synthetic method for 2,5-disubstituted tetrazoles from 5-substituted tetrazoles using cobalt-catalyzed intermolecular hydroamination reaction of nonactivated olefins. Owing to its mild conditions, the method enabled the use of substrates having acid-labile functional groups, such as silyloxy and methoxymethyloxy groups. By using optically active cobalt complexes, asymmetric intermolecular hydroamination of nonactivated olefins, a longstanding challenge in synthetic organic chemistry, was developed to produce optically active disubstituted tetrazoles.
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1
Base de dados:
MEDLINE
Assunto principal:
Tetrazóis
/
Cobalto
/
Alcenos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article