In-Vivo and Ex-Vivo Measurements of Blood Glucose Using Whispering Gallery Modes.
Sensors (Basel)
; 20(3)2020 Feb 04.
Article
em En
| MEDLINE
| ID: mdl-32033139
ABSTRACT
The permittivity of blood glucose is not a strong function of its concentration in microwave or millimeter-wave frequencies. Measuring glucose concentrations remains a challenge, particularly in the presence of interference caused by the ambient leaky waves. In this paper, however, we demonstrate that a near-linear correlation between the glucose concentration and the blood permittivity was noticeably observed at a whispering gallery mode resonance. METHOD:
the proposed sensor was a vacuum suction aspirator partially wounded with a turn of the Goubau line. This arrangement enabled a fixed cylindrical volume of a skin tissue bump or glucose/water solution to be formed and used as a whispering gallery resonator for in-vivo and ex-vivo measurements.RESULTS:
in the in-vivo study, a near-linear correlation between the glucose levels and the S21 parameters was noticeably observed at the fundamental whispering gallery resonance (i.e., at 2.18 GHz). In the ex-vivo study, a similar correlation was observed between the concentration of a glucose/water solution and the S21 parameters 56.6 GHz.CONCLUSION:
the results of both investigations were consistent not only with the invasive measurements using the Accu-checkTM, but also with the conclusion drawn by some other research groups who have successfully measured blood glucose concentrations at millimeter-wave frequencies.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pele
/
Glicemia
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Técnicas Biossensoriais
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Automonitorização da Glicemia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article