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Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib.
Bagnolini, Greta; Milano, Domenico; Manerba, Marcella; Schipani, Fabrizio; Ortega, Jose Antonio; Gioia, Dario; Falchi, Federico; Balboni, Andrea; Farabegoli, Fulvia; De Franco, Francesca; Robertson, Janet; Pellicciari, Roberto; Pallavicini, Isabella; Peri, Sebastiano; Minucci, Saverio; Girotto, Stefania; Di Stefano, Giuseppina; Roberti, Marinella; Cavalli, Andrea.
Afiliação
  • Bagnolini G; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
  • Milano D; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
  • Manerba M; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
  • Schipani F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
  • Ortega JA; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
  • Gioia D; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
  • Falchi F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
  • Balboni A; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
  • Farabegoli F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
  • De Franco F; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
  • Robertson J; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
  • Pellicciari R; TES Pharma S.r.l., Via Palmiro Togliatti 22bis, I-06073 Corciano, Perugia, Italy.
  • Pallavicini I; TES Pharma S.r.l., Via Palmiro Togliatti 22bis, I-06073 Corciano, Perugia, Italy.
  • Peri S; TES Pharma S.r.l., Via Palmiro Togliatti 22bis, I-06073 Corciano, Perugia, Italy.
  • Minucci S; Department of Experimental Oncology at the IEO, European Institute of Oncology IRCCS, IFOM-IEO Campus, Via Adamello 16, 20100 Milan, Italy.
  • Girotto S; Department of Experimental Oncology at the IEO, European Institute of Oncology IRCCS, IFOM-IEO Campus, Via Adamello 16, 20100 Milan, Italy.
  • Di Stefano G; Department of Biosciences, University of Milan, Via Celoria 26, 20100 Milan, Italy.
  • Roberti M; Department of Experimental Oncology at the IEO, European Institute of Oncology IRCCS, IFOM-IEO Campus, Via Adamello 16, 20100 Milan, Italy.
  • Cavalli A; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.
J Med Chem ; 63(5): 2588-2619, 2020 03 12.
Article em En | MEDLINE | ID: mdl-32037829
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Ftalazinas / Piperazinas / Adenocarcinoma / Proteína BRCA2 / Rad51 Recombinase / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Ftalazinas / Piperazinas / Adenocarcinoma / Proteína BRCA2 / Rad51 Recombinase / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article