Aggregation of mutant cysteine string protein-&#945; via Fe-S cluster binding is mitigated by iron chelators.

Naseri, Nima N; Ergel, Burçe; Kharel, Parinati; Na, Yoonmi; Huang, Qingqiu; Huang, Rong; Dolzhanskaya, Natalia; Burré, Jacqueline; Velinov, Milen T; Sharma, Manu

Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.

Naseri, Nima N; Ergel, Burçe; Kharel, Parinati; Na, Yoonmi; Huang, Qingqiu; Huang, Rong; Dolzhanskaya, Natalia; Burré, Jacqueline; Velinov, Milen T; Sharma, Manu.

Afiliação

Naseri NN; Appel Institute for Alzheimer's Disease Research, and Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Ergel B; Appel Institute for Alzheimer's Disease Research, and Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Kharel P; Appel Institute for Alzheimer's Disease Research, and Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Na Y; Appel Institute for Alzheimer's Disease Research, and Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Huang Q; Cornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY, USA.
Huang R; Cornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY, USA.
Dolzhanskaya N; New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
Burré J; Appel Institute for Alzheimer's Disease Research, and Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Velinov MT; New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
Sharma M; Appel Institute for Alzheimer's Disease Research, and Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. mas2189@med.cornell.edu.

Nat Struct Mol Biol ; 27(2): 192-201, 2020 02.

Article em En | MEDLINE | ID: mdl-32042150

Assuntos

Proteínas de Choque Térmico HSP40/genética; Proteínas de Membrana/genética; Lipofuscinoses Ceroides Neuronais/genética; Mutação Puntual; Agregação Patológica de Proteínas/genética; Animais; Células Cultivadas; Feminino; Células HEK293; Proteínas de Choque Térmico HSP40/metabolismo; Humanos; Quelantes de Ferro/metabolismo; Lipoilação; Proteínas de Membrana/metabolismo; Camundongos; Lipofuscinoses Ceroides Neuronais/metabolismo; Neurônios/metabolismo; Agregação Patológica de Proteínas/metabolismo; Ligação Proteica; Multimerização Proteica

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mutação Puntual / Proteínas de Choque Térmico HSP40 / Agregação Patológica de Proteínas / Proteínas de Membrana / Lipofuscinoses Ceroides Neuronais Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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