Oxidative cyanation of 2-oxindoles: formal total synthesis of (±)-gliocladin C.
Org Biomol Chem
; 18(8): 1679-1684, 2020 02 26.
Article
em En
| MEDLINE
| ID: mdl-32052001
ABSTRACT
Efficient oxidative direct cyanations of 3-alkyl/aryl 2-oxindoles using Cyano-1,2-BenziodoXol-3(1H)-one (CBX) (2a) have been reported under 'transition metal-free' conditions to synthesize a wide variety of 3-cyano 3-alkyl/aryl 2-oxindoles sharing an all-carbon quaternary center under additive-free conditions. The application of this process is shown by the formal total synthesis of (±)-gliocladin C (11c) in a few steps.
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MEDLINE
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En
Ano de publicação:
2020
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Article