Statistical optimization and validation of a novel ultra-performance liquid chromatography method for estimation of nintedanib in rat and human plasma.

Shukla, Snehal K; Kadry, Hossam; Bhatt, Jayshil A; Elbatanony, Rasha; Ahsan, Fakhrul; Gupta, Vivek

Shukla, Snehal K; Kadry, Hossam; Bhatt, Jayshil A; Elbatanony, Rasha; Ahsan, Fakhrul; Gupta, Vivek.

Afiliação

Shukla SK; Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John's University, Queens, NY 11432, USA.
Kadry H; School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, TX 79106, USA.
Bhatt JA; Arnold & Marie Schwartz College of Pharmacy, Long Island University, 75 Dekalb Ave L130, Brooklyn, NY 11201, USA.
Elbatanony R; Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John's University, Queens, NY 11432, USA.
Ahsan F; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt.
Gupta V; School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, TX 79106, USA.

Bioanalysis ; 12(3): 159-174, 2020 Feb.

Article em En | MEDLINE | ID: mdl-32052636

Assuntos

Antineoplásicos/sangue; Cromatografia Líquida/métodos; Indóis/sangue; Animais; Antineoplásicos/farmacologia; Humanos; Indóis/farmacologia; Ratos

Palavras-chave

UPLC-UV; design of experiments (DOE); nintedanib; pharmacokinetics; preclinical; principal component analysis (PCA); statistical analysis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Indóis / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Indóis / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article