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Design, synthesis and biological evaluation of HIV-1 protease inhibitors with morpholine derivatives as P2 ligands in combination with cyclopropyl as P1' ligand.
Dou, Yue; Zhu, Mei; Dong, Biao; Wang, Ju-Xian; Zhang, Guo-Ning; Zhang, Fan; Wang, Yu-Cheng.
Afiliação
  • Dou Y; School of Pharmacy, Jinzhou Medical University, Jinzhou 121001, PR China.
  • Zhu M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
  • Dong B; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
  • Wang JX; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
  • Zhang GN; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
  • Zhang F; School of Pharmacy, Jinzhou Medical University, Jinzhou 121001, PR China. Electronic address: zhangfan830720@163.com.
  • Wang YC; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China. Electronic address: wangyucheng@imb.pumc.edu.cn.
Bioorg Med Chem Lett ; 30(7): 127019, 2020 04 01.
Article em En | MEDLINE | ID: mdl-32057582
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Morfolinas / Protease de HIV / Inibidores da Protease de HIV Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Morfolinas / Protease de HIV / Inibidores da Protease de HIV Idioma: En Ano de publicação: 2020 Tipo de documento: Article