Proteogenomic Characterization of Endometrial Carcinoma.
Cell
; 180(4): 729-748.e26, 2020 02 20.
Article
em En
| MEDLINE
| ID: mdl-32059776
ABSTRACT
We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/ß-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma
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Regulação Neoplásica da Expressão Gênica
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Neoplasias do Endométrio
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Proteoma
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Transcriptoma
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article