TLR5 Activation Exacerbates Airway Inflammation in Asthma.

Whitehead, G S; Hussain, S; Fannin, R; Trempus, C S; Innes, C L; Schurman, S H; Cook, D N; Garantziotis, S

Whitehead, G S; Hussain, S; Fannin, R; Trempus, C S; Innes, C L; Schurman, S H; Cook, D N; Garantziotis, S.

Afiliação

Whitehead GS; Immunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Hussain S; Immunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Fannin R; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV, 26506, USA.
Trempus CS; Molecular Genomics Core Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Innes CL; Immunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Schurman SH; Clinical Research Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Cook DN; Clinical Research Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Garantziotis S; Immunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.

Lung ; 198(2): 289-298, 2020 04.

Article em En | MEDLINE | ID: mdl-32060608

Assuntos

Asma/metabolismo; Hiper-Reatividade Brônquica/metabolismo; Broncoconstrição; Pulmão/metabolismo; Receptor 5 Toll-Like/metabolismo; Adulto; Animais; Asma/induzido quimicamente; Asma/imunologia; Asma/fisiopatologia; Hiper-Reatividade Brônquica/induzido quimicamente; Hiper-Reatividade Brônquica/imunologia; Hiper-Reatividade Brônquica/fisiopatologia; Estudos de Casos e Controles; Estudos Transversais; Citocinas/metabolismo; Modelos Animais de Doenças; Feminino; Flagelina; Células HEK293; Humanos; Pulmão/imunologia; Pulmão/fisiopatologia; Masculino; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Ovalbumina; Polimorfismo de Nucleotídeo Único; Transdução de Sinais; Células Th1/imunologia; Células Th1/metabolismo; Receptor 5 Toll-Like/genética

Palavras-chave

Airway inflammation; Asthma; Flagellin; TLR5

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Broncoconstrição / Hiper-Reatividade Brônquica / Receptor 5 Toll-Like / Pulmão Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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