Association between interleukin gene polymorphisms and multiple myeloma susceptibility.

ABSTRACT

The present study performed a retrospective observational study in order to investigate the relationship between the interleukin family gene polymorphisms and risk of multiple myeloma (MM), based on sixteen case-control studies that contained 2,597 patients with MM and 3,851 controls. The results demonstrated that the genotypes IL-6 and IL-1 GG increased the risk of MM by approximately 40.8 and 80.2% compared with the genotypes AA and CC [odds ratio (OR)=1.14, 95% confidence interval (CI), 0.88-1.47, and OR=1.16, 95% CI, 0.61-2.19; respectively]. The results also revealed a significant association between TC polymorphism of the IL-6 and IL-10 and the risk of MM (TC/CC OR=1.37, 95% CI, 0.88-2.16 and TT/CC OR=1.26, 95% CI, 0.77-2.06, respectively). Additionally, no significant association was identified between the CA polymorphisms of the IL-6 (rs8192284) and IL-10 (rs1800872) receptors and the overall risk of MM (P>0.05). GC polymorphisms of the IL-1ß1464G>C and IL-6572G>C significantly increased the risk of MM (P<0.05). However, it has been determined that there is a significant association between the CT polymorphism of the IL-1α-889C>T and IL-1ß-3737C>T and the risk of MM (P<0.001). Subgroup analysis revealed that the detection of GA polymorphisms in the IL-6 promoter (OR=1.05, 95% CI, 0.78-1.44) is more accurate in MM samples of the Asian population (OR=1.24, 95% CI, 0.92-1.74). In addition, no significant association was identified between the IL gene polymorphisms in MM samples categorized by ethnicity and the IL family type (P=0.27). These single nucleotide polymorphism loci may be the appropriate gene markers for gene screening and a promising therapeutic strategy in the prognostics of patients with MM.