MicroRNA-320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element-binding protein 1.
Cancer Med
; 9(8): 2833-2845, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32064777
ABSTRACT
Osteosarcoma is a primary malignant bone tumor, which affects children, adolescents, and young adults commonly. MicroRNAs (miRNAs) have been proved to be dysregulated in different cancers, including osteosarcoma. Although miR-320a has been implicated in many types of malignancies, little is known about the role of miR-320a in osteosarcoma. In this study, we show that the overexpression of miR-320a or knockdown of cytoplasmic polyadenylation element-binding protein 1 (CPEB1) inhibited osteosarcoma cell migration and invasion. miR-320a downregulates CPEB1 expression by directly targeting the CPEB1 3'-UTR. Furthermore, CPEB1 reintroduction reversed the antiproliferation, antimigration, and antiinvasion roles of miR-320a, indicating that miR-320a might function as a tumor suppressor in osteosarcoma through CPEB1. In conclusion, our study demonstrates that miR-320a plays a critical role in osteosarcoma progression and may provide a potential therapeutic target for osteosarcoma.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Neoplasias Ósseas
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Biomarcadores Tumorais
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Osteossarcoma
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Regulação Neoplásica da Expressão Gênica
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Fatores de Poliadenilação e Clivagem de mRNA
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MicroRNAs
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article