Heterozygotes for ACAN dwarfism alleles in horses have reduced stature.
Anim Genet
; 51(3): 420-422, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32065671
ABSTRACT
Homozygous and compound heterozygous Miniature horses for ACAN alleles D1, D2, D3* and D4 exhibit chondrodysplastic dwarfism (OMIA 001271-9796). In a previous study, the carrier rate for these four alleles, combined, was 26.2%. The purpose of this study was to investigate whether carriers of these dwarfism-causing alleles had a shorter withers height than non-carriers. A total of 245 Miniature horses were tested for these four ACAN alleles and also were measured for withers height. Of these horses, 98 were carriers and 147 were non-carriers. A statistically significant difference of 1.43 inches was observed with the carriers being shorter (P = 1.72E - 11). The range of heights for the two groups overlapped, indicating that other factors, including genes, have an impact on withers height. However, the high carrier rate of these dwarfism-causing variants may be due to selection for decreased height.
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Base de dados:
MEDLINE
Assunto principal:
Nanismo
/
Agrecanas
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Doenças dos Cavalos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article