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Relationship between morphological and vascular alterations in geographic atrophy using a multimodal imaging approach.
Hecht, Alexander; Pollreisz, Andreas; Sayegh, Ramzi; Told, Reinhard; Baratsits, Magdalena; Baumann, Bernhard; Pircher, Michael; Hitzenberger, Christoph K; Sacu, Stefan; Schmidt-Erfurth, Ursula.
Afiliação
  • Hecht A; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
  • Pollreisz A; Department of Ophthalmology, Vienna Clinical Trial Center, Medical University of Vienna, Vienna, Austria.
  • Sayegh R; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
  • Told R; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
  • Baratsits M; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
  • Baumann B; Department of Ophthalmology, Vienna Clinical Trial Center, Medical University of Vienna, Vienna, Austria.
  • Pircher M; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
  • Hitzenberger CK; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
  • Sacu S; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
  • Schmidt-Erfurth U; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
Acta Ophthalmol ; 98(6): e700-e708, 2020 Sep.
Article em En | MEDLINE | ID: mdl-32067383
PURPOSE: To assess geographic atrophy (GA) using a multimodal imaging approach, focusing on alterations at the level of the retinal pigment epithelium (RPE) and the choriocapillaris (CC) layers, by lesion demarcation, and assessment of morphological alterations within the atrophic area and in the transition zone. METHODS: Fifty-seven eyes of 34 patients with atrophic age-related macular degeneration (AMD) were included in this prospective, observational, cross-sectional study. Multimodal imaging using wide-field polarization-sensitive optical coherence tomography (PS-OCT), optical coherence tomography angiography (OCT-A) and fundus autofluorescence (FAF) was performed. The images were overlaid and used to analyse and compare alterations in the retina and the CC. RESULTS: Mean atrophic lesion size was 8.15 mm2 (range: 2.23-17.23 mm2 ). In 52 of 57 eyes (91%), OCT-A displayed focal hypodense areas at the CC level in the transition zone of GA, as well as increased focal depolarizing material (e.g. melanin-containing structures) showed in PS-OCT en face depolarizing material maps. These regions of increased depolarizing material at the transition zone corresponded to the hypodense areas on OCT-A scans. All 57 eyes presented with abnormal FAF patterns at the transition zone. All 57 eyes showed distinct alterations of CC flow pattern architecture. Six eyes (11%) demonstrated reduced and three eyes (5%) a complete loss of CC flow pattern architecture across the entire area of GA, while 48 of 57 eyes (84%) presented with irregular mixed patterns of different focal alterations of CC flow architecture within the area of GA. Reduced CC patterns exceeding GA lesion margins into the transitional zone were found in all eyes. CONCLUSIONS: Optical coherence tomography angiography images revealed different degrees of flow impairment within the atrophic lesion area and its transition zone. Alterations in RPE morphology and tissue integrity resulting in accumulation of depolarizing material, such as melanin, could result in misinterpretation of OCT-A imaging in areas in the shadow of depolarizing material. These changes seem to be partially independent from autofluorescence altering processes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Angiofluoresceinografia / Corioide / Tomografia de Coerência Óptica / Epitélio Pigmentado da Retina / Atrofia Geográfica Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Angiofluoresceinografia / Corioide / Tomografia de Coerência Óptica / Epitélio Pigmentado da Retina / Atrofia Geográfica Idioma: En Ano de publicação: 2020 Tipo de documento: Article