Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration.
BMC Ophthalmol
; 20(1): 56, 2020 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-32070305
ABSTRACT
BACKGROUND:
Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD.METHODS:
Blood serum samples were collected from 34 patients with nAMD (mean age 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined.RESULTS:
In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men 2241 ± 549 vs. 2136 ± 246 µmol/L; women 2263 ± 292 vs. 2335 ± 161 µmol/L).CONCLUSION:
The d-ROMs test may provide a useful indicator of nAMD in men but not in women.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Espécies Reativas de Oxigênio
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Estresse Oxidativo
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Neovascularização de Coroide
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Degeneração Macular Exsudativa
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Antioxidantes
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article