Empagliflozin improved systolic blood pressure, endothelial dysfunction and heart remodeling in the metabolic syndrome ZSF1 rat.

Park, Sin-Hee; Farooq, Muhammad Akmal; Gaertner, Sébastien; Bruckert, Christophe; Qureshi, Abdul Wahid; Lee, Hyun-Ho; Benrahla, Djamel; Pollet, Brigitte; Stephan, Dominique; Ohlmann, Patrick; Lessinger, Jean-Marc; Mayoux, Eric; Auger, Cyril; Morel, Olivier; Schini-Kerth, Valérie B

Park, Sin-Hee; Farooq, Muhammad Akmal; Gaertner, Sébastien; Bruckert, Christophe; Qureshi, Abdul Wahid; Lee, Hyun-Ho; Benrahla, Djamel; Pollet, Brigitte; Stephan, Dominique; Ohlmann, Patrick; Lessinger, Jean-Marc; Mayoux, Eric; Auger, Cyril; Morel, Olivier; Schini-Kerth, Valérie B.

Afiliação

Park SH; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
Farooq MA; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
Gaertner S; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
Bruckert C; Hôpitaux Universitaires de Strasbourg, Service des Maladies Vasculaires - Hypertension Artérielle, Strasbourg, France.
Qureshi AW; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
Lee HH; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
Benrahla D; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
Pollet B; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
Stephan D; UMR CNRS 7021 Laboratoire de Bioimagerie et Pathologies, Strasbourg, France.
Ohlmann P; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.
Lessinger JM; Hôpitaux Universitaires de Strasbourg, Service des Maladies Vasculaires - Hypertension Artérielle, Strasbourg, France.
Mayoux E; Hôpitaux Universitaires de Strasbourg, Service de Cardiologie, Strasbourg, France.
Auger C; Laboratory of Biochemistry and Molecular Biology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Morel O; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
Schini-Kerth VB; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.

Cardiovasc Diabetol ; 19(1): 19, 2020 02 18.

Article em En | MEDLINE | ID: mdl-32070346

Assuntos

Compostos Benzidrílicos/farmacologia; Pressão Sanguínea/efeitos dos fármacos; Endotélio Vascular/efeitos dos fármacos; Glucosídeos/farmacologia; Síndrome Metabólica/tratamento farmacológico; Inibidores do Transportador 2 de Sódio-Glicose/farmacologia; Função Ventricular Esquerda/efeitos dos fármacos; Remodelação Ventricular/efeitos dos fármacos; Animais; Biomarcadores/sangue; Glicemia/efeitos dos fármacos; Glicemia/metabolismo; Senescência Celular/efeitos dos fármacos; Modelos Animais de Doenças; Endotélio Vascular/metabolismo; Endotélio Vascular/fisiopatologia; Síndrome Metabólica/etiologia; Síndrome Metabólica/metabolismo; Síndrome Metabólica/fisiopatologia; Obesidade/complicações; Ratos Zucker; Sístole

Palavras-chave

Empagliflozin; Endothelial function; Heart function; Heart structure; Metabolic syndrome; SGLT2; Senescence; ZSF1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Benzidrílicos / Pressão Sanguínea / Endotélio Vascular / Função Ventricular Esquerda / Remodelação Ventricular / Síndrome Metabólica / Inibidores do Transportador 2 de Sódio-Glicose / Glucosídeos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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