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Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin.
Schmerer, Matthew W; Abrams, A Jeanine; Seby, Sandra; Thomas, Jesse C; Cartee, John; Lucking, Sean; Vidyaprakash, Eshaw; Pham, Cau D; Sharpe, Samera; Pettus, Kevin; St Cyr, Sancta B; Torrone, Elizabeth A; Kersh, Ellen N; Gernert, Kim M.
Afiliação
  • Schmerer MW; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA mschmerer@cdc.gov.
  • Abrams AJ; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Seby S; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Thomas JC; Oak Ridge Institute for Science and Education Research Participation and Fellowship Program, Oak Ridge, Tennessee, USA.
  • Cartee J; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Lucking S; Oak Ridge Institute for Science and Education Research Participation and Fellowship Program, Oak Ridge, Tennessee, USA.
  • Vidyaprakash E; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Pham CD; Oak Ridge Institute for Science and Education Research Participation and Fellowship Program, Oak Ridge, Tennessee, USA.
  • Sharpe S; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Pettus K; Oak Ridge Institute for Science and Education Research Participation and Fellowship Program, Oak Ridge, Tennessee, USA.
  • St Cyr SB; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Torrone EA; Oak Ridge Institute for Science and Education Research Participation and Fellowship Program, Oak Ridge, Tennessee, USA.
  • Kersh EN; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gernert KM; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Antimicrob Agents Chemother ; 64(5)2020 04 21.
Article em En | MEDLINE | ID: mdl-32071056
ABSTRACT
In 2016, the proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 N. gonorrhoeae isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 µg/ml that carried a mosaic-like mtr locus, whereas the majority of isolates with MICs of ≥16 µg/ml appeared sporadically and carried 23S rRNA mutations. Continued molecular surveillance of N. gonorrhoeae isolates will identify new resistance mechanisms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azitromicina / Vigilância de Evento Sentinela / Farmacorresistência Bacteriana / Antibacterianos / Neisseria gonorrhoeae Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azitromicina / Vigilância de Evento Sentinela / Farmacorresistência Bacteriana / Antibacterianos / Neisseria gonorrhoeae Idioma: En Ano de publicação: 2020 Tipo de documento: Article