The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins.

Touzelet, Olivier; Broadbent, Lindsay; Armstrong, Stuart D; Aljabr, Waleed; Cloutman-Green, Elaine; Power, Ultan F; Hiscox, Julian A

Touzelet, Olivier; Broadbent, Lindsay; Armstrong, Stuart D; Aljabr, Waleed; Cloutman-Green, Elaine; Power, Ultan F; Hiscox, Julian A.

Afiliação

Touzelet O; Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool L3 5RF, UK; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queens University Belfast, Belfast BT9 7BL, UK.
Broadbent L; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queens University Belfast, Belfast BT9 7BL, UK.
Armstrong SD; Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool L3 5RF, UK; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, L69 7BE, UK.
Aljabr W; Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool L3 5RF, UK; Biomedical Research Administration, Research Centre, King Fahad Medical City, P.O. Box 59046 Riyadh 11252, Saudi Arabia.
Cloutman-Green E; Microbiology, Virology and Infection Control, Level 4 Camelia Botnar Laboratory, Great Ormond Street Hospital, London WC1N 3JH, UK.
Power UF; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queens University Belfast, Belfast BT9 7BL, UK. Electronic address: u.power@qub.ac.uk.
Hiscox JA; Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool L3 5RF, UK; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, L69 7BE, UK; Singapore Immunology Network, Agency for Science, Technology and R

Mol Cell Proteomics ; 19(5): 793-807, 2020 05.

Article em En | MEDLINE | ID: mdl-32075873

Assuntos

Antivirais/metabolismo; Quimiocinas/metabolismo; Proteoma/metabolismo; Mucosa Respiratória/virologia; Infecções por Vírus Respiratório Sincicial/imunologia; Infecções por Vírus Respiratório Sincicial/virologia; Vírus Sincicial Respiratório Humano/fisiologia; Brônquios/patologia; Linhagem Celular; Criança; Células Epiteliais/patologia; Células Epiteliais/virologia; Células Caliciformes/metabolismo; Células Caliciformes/virologia; Homeostase; Humanos; Lactente; Cinética; Nasofaringe/virologia; Mucosa Respiratória/metabolismo; Vírus Sincicial Respiratório Humano/crescimento & desenvolvimento; Tropismo; Proteínas Virais/metabolismo

Palavras-chave

CEACAM1; CSF3; CXCL6; Cell secretion; cytokines; host-pathogen interaction; label-free quantification; lung function or biology; mass spectrometry; respiratory syncytial virus; secretome; viruses; well-differentiated pediatric bronchial epithelial cells (WD-PBECs)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial / Quimiocinas / Mucosa Respiratória / Proteoma Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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