Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases.
Metab Syndr Relat Disord
; 18(4): 186-196, 2020 05.
Article
em En
| MEDLINE
| ID: mdl-32077785
ABSTRACT
Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, numerous pathological and physiological functions related to cell proliferation, migration, and inflammation have been reported. Notably, the expression of HB-EGF is sensitively upregulated by oxidative stress in the endothelial cells and functions for auto- and paracrine-EGFR signaling. Overnutrition and obesity cause elevation of HB-EGF expression and EGFR signaling in the hepatic and vascular systems. Modulations of HB-EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.
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Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
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Fator de Crescimento Semelhante a EGF de Ligação à Heparina
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Doenças Metabólicas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article