Phenotype-based probabilistic analysis of heterogeneous responses to cancer drugs and their combination efficacy.

Comandante-Lou, Natacha; Khaliq, Mehwish; Venkat, Divya; Manikkam, Mohan; Fallahi-Sichani, Mohammad

Comandante-Lou, Natacha; Khaliq, Mehwish; Venkat, Divya; Manikkam, Mohan; Fallahi-Sichani, Mohammad.

Afiliação

Comandante-Lou N; Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Khaliq M; Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Venkat D; Program in Cancer Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Manikkam M; Department of Biochemistry, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Fallahi-Sichani M; Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

PLoS Comput Biol ; 16(2): e1007688, 2020 02.

Article em En | MEDLINE | ID: mdl-32084135

Assuntos

Antineoplásicos/uso terapêutico; Interações Medicamentosas; Quimioterapia Combinada; Neoplasias/tratamento farmacológico; Neoplasias/fisiopatologia; Probabilidade; Linhagem Celular Tumoral; Terapia Combinada; Simulação por Computador; Humanos; Melanoma/tratamento farmacológico; Melanoma/fisiopatologia; Modelos Estatísticos; Fenótipo; Distribuição de Poisson

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Probabilidade / Interações Medicamentosas / Quimioterapia Combinada / Neoplasias / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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