Novel Prognostic Models for Myelodysplastic Syndromes.
Hematol Oncol Clin North Am
; 34(2): 369-378, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32089216
ABSTRACT
Myelodysplastic syndromes are disorders of clonal myelopoiesis having a range of clinical manifestations, from benign and indolent to aggressive with very poor prognosis. Classifying the likely trajectory of disease within a patient largely guides therapeutic decision making and therefore survival. Traditional methods of risk-stratification systems rely on clinical features simple blood tests, peripheral smears, bone marrow biopsies, and cytogenetics, but do not adequately predict disease severity for a substantial proportion of patients. This article reviews the state of stratification at use in the clinic, describes emerging systems that leverage large-scale genomic data, and summarizes efforts toward truly personalized prediction models.
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Base de dados:
MEDLINE
Assunto principal:
Síndromes Mielodisplásicas
/
Modelos Biológicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article