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Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes.
Werner, Stephan; Schmidt, Lukas; Marchand, Virginie; Kemmer, Thomas; Falschlunger, Christoph; Sednev, Maksim V; Bec, Guillaume; Ennifar, Eric; Höbartner, Claudia; Micura, Ronald; Motorin, Yuri; Hildebrandt, Andreas; Helm, Mark.
Afiliação
  • Werner S; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
  • Schmidt L; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
  • Marchand V; Epitranscriptomics and Sequencing (EpiRNA-Seq) Core Facility, UMS2008 IBSLor CNRS-Université de Lorraine-INSERM, Biopôle, 9 Avenue de la Forêt de Haye, 54505 Vandœuvre-lès-Nancy, France.
  • Kemmer T; Institute of Computer Science, Johannes Gutenberg-University Mainz, Staudingerweg 9, 55128 Mainz, Germany.
  • Falschlunger C; Department of Organic Chemistry, Leopold Franzens University Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
  • Sednev MV; Institute of Organic Chemistry, Julius Maximilian University Würzburg, Am Hubland, 97074 Würzburg, Germany.
  • Bec G; IBMC, UPR9002 CNRS-Université de Strasbourg, 2 Allée Konrad Roentgen, 67084 Strasbourg, France.
  • Ennifar E; IBMC, UPR9002 CNRS-Université de Strasbourg, 2 Allée Konrad Roentgen, 67084 Strasbourg, France.
  • Höbartner C; Institute of Organic Chemistry, Julius Maximilian University Würzburg, Am Hubland, 97074 Würzburg, Germany.
  • Micura R; Department of Organic Chemistry, Leopold Franzens University Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
  • Motorin Y; Epitranscriptomics and Sequencing (EpiRNA-Seq) Core Facility, UMS2008 IBSLor CNRS-Université de Lorraine-INSERM, Biopôle, 9 Avenue de la Forêt de Haye, 54505 Vandœuvre-lès-Nancy, France.
  • Hildebrandt A; IMoPA, UMR7365 CNRS-Université de Lorraine, Biopôle, 9 Avenue de la Forêt de Haye, 54505 Vandœuvre-lès-Nancy, France.
  • Helm M; Institute of Computer Science, Johannes Gutenberg-University Mainz, Staudingerweg 9, 55128 Mainz, Germany.
Nucleic Acids Res ; 48(7): 3734-3746, 2020 04 17.
Article em En | MEDLINE | ID: mdl-32095818
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Polimerase Dirigida por RNA / Transcrição Reversa Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Polimerase Dirigida por RNA / Transcrição Reversa Idioma: En Ano de publicação: 2020 Tipo de documento: Article